Developing biocompatible chemistries

There are several hundred chemically distinct PTMs and most can be rapidly applied or removed. They are chemically diverse and applied, by nature, in a highly selective way. Chemical approaches, despite many advancements, still face challenges related to water compatibility and substrate stability, which restrict their applicability across various protein types. To address these challenges new chemistries are needed to recreate these modifications to modulate and control cellular networks, to maintain or control function. Our research explores a wide range of light-, redox-, metal- mediated chemistries with the intention of creating a general palette of reactions that control organismal target physiology and the ability to focus on ‘trigger’ pathways.