Dr Brian Caffrey
Brian Caffrey is a postdoctoral researcher and specialist in correlated microscopy methods. His research focuses on the application of advanced microscopy methods to probe the biomolecular basis of disease. At the Rosalind Franklin Institute, he is developing liquid phase electron microscopy and electron spectroscopy methods for application in biology. He is currently working on multimodal staining methods for high resolution imaging in cancer biology and microbiology.
Aberration-corrected transmission electron microscope
Ruska is an aberration-corrected transmission electron microscope (TEM) used to explore novel methods to study radiation sensitive specimens such as biological materials that have been cryogenically preserved or encapsulated in liquid for dynamic observations.
Chromatic Correction
Knoll, the first chromatic aberration-corrected electron microscope in the UK housed at the Franklin, will push the current resolution limits for biological samples by correcting energy variations in the electron beam.
Liquid Phase Electron Microscopy and Spectroscopy
Transient, dynamic assemblies of biomolecules in solution are the primary driving forces behind biology. However, studying these at high resolutions requires the use of electron microscopes (EM), which need extremely high vacuums to function.