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Structural Biology

Dr Michael Grange

Tomography Group Leader

Michael completed his D.Phil in structural biology at the University of Oxford, UK, where he applied FIB milling, electron cryo-tomography (cryoET) and super-resolution microscopy to investigate the trafficking and egress of viral progeny within cells.

After his doctoral studies, he moved to the Max Planck Institute for Molecular Physiology, Germany, as an EMBO Long-Term Fellow. During his fellowship, he established cryoET as a core method, was involved in establishing high-throughput FIB-milling workflows, and combined them to investigate the structure and architecture of isolated mammalian muscle and human stem-cell-derived cardiomyocytes.

In 2021, he joined the Franklin as a group leader where his research uses in-situ structural techniques to determine the impact of disease-relevant genetic alterations on the structural cell biology of axonal plasticity, with an emphasis on cytoskeletal trafficking and structural alterations within the neuron. He also develops methods for cryoET and the correlative imaging of larger tissues for structural studies.

View Michael’s publications here.

Rosalind Franklin Institute