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Dr Narain Karedla

Postdoctoral Advanced Microscopy Specialist

Narain is a postdoctoral researcher and an advanced microscopy specialist. He will be building a lattice light sheet microscope coupled with structured illumination and adaptive optics. This microscope will allow acquisition of 3D super-resolution volumetric data at one to two orders of magnitude faster than conventional fluorescence techniques and it will serve as a powerful tool to interrogate and correlate biophysical events within single cells and cells in their tissue environments.

He is an experimental physicist by training with a deep motivation in developing and exploring new advanced optical tools. During his doctoral studies at Goettingen, Germany, he developed and worked on several single molecule spectroscopy and super-resolution techniques for biophysical applications. One notable example is metal-induced energy transfer (MIET) that is capable of localizing individual fluorescent emitters with isotropic 3D nanometer resolution. During his postdoctoral training at Oxford, he built a new method for quantifying electrostatic surface charge density of solids immersed in fluids using optical microscopy. This method also allows for the direct measurement of effective charges of biomolecules in solution, a fundamental characteristic that is crucial to study ligand-receptor binding interactions and structure-charge interrelationship of biomolecules.

View Narain’s publications here.

Rosalind Franklin Institute