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Structural Biology

Dr John Clarke

Postdoctoral Research Scientist in Protein Science

John is a postdoctoral researcher within the Structural Biology Nanobody Discovery team. John’s research looks to discover, optimise, and engineer novel biologics based on the nanobody platform for use in therapeutics to combat COVID-19 in SARS-CoV-2 infections as part of the industrial collaboration.

Previously, John completed his interdisciplinary doctoral project with the University of Oxford, Diamond Light Source and The Pirbright Institute in March 2023. He used crystallographic X-Ray diffraction, single-particle cryogenic electron microscopy and several biophysical techniques (SEC-MALS, AUC, BLI) to examine the eccentricities of bovine adaptive immune responses. John then engineered 15 nanobodies, providing biomolecular probes for the functional, structural, and physiological characterisation of the relatively underreported K2P ion channels in collaboration with the Tucker Lab at the University of Oxford.

John first graduated from the University of Southampton with a Masters in Biochemistry in June 2018. During his undergraduate studies John researched a proposed mechanism for antimicrobial resistance involving bacterial multidrug resistance efflux pumps, and a short pharmaceutical research project involving Caenorhabditis elegans.

View John’s publications here

Rosalind Franklin Institute