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Lara Fragapane

PhD Student

Thesis title: Solving the mysteries of human protein N-glycosylation: The Early Lipid-Linked Oligosaccharide Synthesis Pathway

Primary Themes: Structural Biology and Next Generation Chemistry

Franklin supervisors: Dr Liang Wu and Dr Andrew Giltrap

University: University of Oxford

University supervisor: Dr Yin Yao Dong

Her project utilises Franklin’s cutting-edge technologies to yield key structural and mechanistic insights of multi-glycosyltransferase complexes involved in the early N-glycosylation pathway and how they are implicated in Congenital Disorders of Glycosylation.

Lara graduated with a BSc in Biochemistry from the University of Bath. During her professional placement year at the European Synchrotron Radiation Facility (ESRF) and the Institut Laue-Langevin (ILL), in Grenoble, she developed an interest in structural and molecular biology. Here, she used techniques, including X-ray crystallography, small-angle X-ray scattering and neutron reflectometry to study the therapeutic properties of the polyphenolic compound, curcuminoids. Continuing with a focus in structural biology, her final year research project involved the structural studies of the botulinum neurotoxin serotype B/translocation domain. She is excited to work within an interdisciplinary environment at the Franklin and collaborate with others to address current health research challenges.

Read Lara’s publications here

Rosalind Franklin Institute