Home Core technologies

The Franklin is developing a unique suite of techniques where we can push developments that are synergistic and impactful. We work with interdisciplinary research teams, developers, engineers and manufacturers to create novel technologies both in-house and collaboratively with partners.


Cryo atomic level protein imaging

We are working to develop technologies in the areas of mass spectrometry and electron microscopy which will allow cells and tissues to be imaged at psuedo atomic resolution, enabling a molecular scale view of the target.


Dynamic imaging of living systems and functional biological models

To fully understand biological structure and function it is necessary to study molecules in their native state. The Franklin will develop PET, light and electron microscopy technologies and techniques, which will allow us to capture systems in motion at different scales.


Enablement of site-specific control by chemical means of proteins inside living systems

Proteins and other macromolecules can be edited in bio-compatible and site-specific fashion, enabling precision control over their properties in in vitro, cell and tissue contexts.


Generating libraries of protein binders and novel chemical ligands

Screening by phenotype to generate libraries of novel protein binders (nanobodies) or chemical ligands. These methods open up new ways of tagging sites of interest and enabling precision editing of molecules.


Machine learning and artificial intelligence applied to organismal biology

Machine Learning and Artificial Intelligence plays a key role in data processing and analysis at the Franklin. Exploiting cutting-edge methods and high-quality experimental data – they automate the mundane to highlight the extraordinary.

Collaborate with us

We want to partner with many different types of organisation and use our technologies to help answer research problems across life science, to enable this we have various routes by which you can collaborate with us.

Collaborate with us
Rosalind Franklin Institute