Researchers

Dr Ben Rowlinson

NMR Facilities Manager
About
Ben is a researcher in NMR spectroscopy with a particular interest in using NMR to investigate protein structure and dynamics. He completed his PhD at the university of York in 2018 where he was working on developing Isotopic labelling tools to aid NMR studies of protein structure and characterising the intrinsically disordered protein LIMD1.  Ben then moved onto a postdoctoral position at the university of Leeds where he worked on the TonB dependent uptake system that allows gram-negative bacteria to uptake scarce or large nutrients across the outer membrane. Here he used NMR spectroscopy and single-molecule FRET to characterise the structure and biophysics of TonB under a range of solution conditions and coupled these findings with in vivo assays to elucidate a mechanism for TonB activity.
Publications

Zn<SUP>2<bold>+</bold> </SUP> Binding Shifts the Conformational Ensemble of α-Synuclein Monomers toward Accelerated Amyloid Formation

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

2025, Journal Article

DOI: 10.1021/JACS.5C11056

Residues 2-7 of α-synuclein regulate amyloid formation via lipid-dependent and -independent pathways

Proceedings Of The National Academy Of Sciences Of The United States Of America

20 Aug 2024, Journal Article

DOI: 10.1073/pnas.2315006121

Broad Spectrum Enantioselective Amide Bond Synthetase from Streptoalloteichus hindustanus

ACS CATALYSIS

2024, Journal Article

DOI: 10.1021/ACSCATAL.3C05656

Biocatalytic Synthesis of Moclobemide Using the Amide Bond Synthetase McbA Coupled with an ATP Recycling System

ACS CATALYSIS

2020, Journal Article

DOI: 10.1021/ACSCATAL.0C00929

Identification and characterization of cytochrome P450 1232A24 and 1232F1 from <i>Arthrobacter</i> sp. and their role in the metabolic pathway of papaverine

JOURNAL OF BIOCHEMISTRY

2019, Journal Article

DOI: 10.1093/JB/MVZ010

The Broad Aryl Acid Specificity of the Amide Bond Synthetase McbA Suggests Potential for the Biocatalytic Synthesis of Amides

ANGEWANDTE CHEMIE INTERNATIONAL EDITION

2018, Journal Article

DOI: 10.1002/ANIE.201804592