Challenge Leadership Group

Professor Helen Cooper

Science Director and Challenge Lead
About

Helen J. Cooper is Science Director and Challenge Lead for Integrated Chemical Imaging in Cells and Tissues at the Franklin, and Professor of Mass Spectrometry in the School of Biosciences at the University of Birmingham.

She undertook her BSc in Chemistry at the University of Warwick, before going on to study for her PhD under the supervision of Peter Derrick. After her PhD, she remained at the University of Warwick as technical officer in the newly-created EPSRC national FT-ICR mass spectrometry facility. In 2000, she moved to the National High Magnetic Field Laboratory at Florida State University to work with Prof Alan Marshall. She returned to the UK in 2003 to establish an independent career at the University of Birmingham. She has been the recipient of a Wellcome Trust University Technology Fellowship and an EPSRC Established Career Fellowship.

Helen’s research focuses on developing native ambient mass spectrometry methods for in situ analysis of proteins. She is Associate Editor of the Journal of the American Society for Mass Spectrometry. She is a Fellow of the Royal Society of Chemistry and winner of the 2022 Royal Society of Chemistry Theophilus Redwood Award for analytical chemistry.

Projects and Platforms
Publications

Native Ambient Mass Spectrometry of an Intact Membrane Protein Assembly and Soluble Protein Assemblies Directly from Lens Tissue

Angewandte Chemie (International Edition)

1 Aug 2022, Journal Article

DOI: 10.1002/anie.202201458

Mass Spectrometry Detection and Imaging of a Non-Covalent Protein-Drug Complex in Tissue from Orally Dosed Rats

Angewandte Chemie (International Edition)

13 Jul 2022, Journal Article

DOI: 10.1002/anie.202202075

Quantitative Characterization of Three Carbonic Anhydrase Inhibitors by LESA Mass Spectrometry

Journal Of The American Society For Mass Spectrometry

6 Jul 2022, Journal Article

DOI: 10.1021/jasms.2c00024

Native ambient mass spectrometry of intact protein assemblies directly from Escherichia coli colonies

Chemical Communications

18 Jun 2022, Journal Article

DOI: 10.1039/D2CC02085H

Discovery, validation, and diagnostic ability of multiple protein-based biomarkers in saliva and gingival crevicular fluid to distinguish between health and periodontal diseases

Journal Of Clinical Periodontology

22 Apr 2022, Journal Article

DOI: 10.1111/jcpe.13630

Native Ambient Mass Spectrometry Enables Analysis of Intact Endogenous Protein Assemblies up to 145 kDa Directly from Tissue

Analytical Chemistry

12 Apr 2022, Journal Article

DOI: 10.1021/acs.analchem.1c05353

Native Ambient Mass Spectrometry Imaging of Ligand-Bound and Metal-Bound Proteins in Rat Brain

Journal Of The American Chemical Society

9 Feb 2022, Journal Article

DOI: 10.1021/jacs.1c10032

Structural proteomics and protein complexes – special issue

Proteomics

14 Nov 2021, Other

DOI: 10.1002/pmic.202000286