Researchers

Professor Marco Fritzsche

Rosalind Franklin Kennedy Trust Research Fellow
About

Professor Marco Fritzsche is the Scientific Director of the Oxford-ZEISS Centre of Excellence and Rosalind Franklin Kennedy Trust Research Fellow who leads the Biophysical Immunology Laboratory (www.bpi-oxford.com) between the Rosalind Franklin Institute and the Kennedy Institute for Rheumatology at the University of Oxford, UK. The BPI Laboratory aims to unravel the impact of biophysics and mechanobiology on the human immune response in health and disease. For this mission, the BPI lab develops custom-built microscopy technology at the interface of biophysics and immunology.

Prof Fritzsche holds a BSc in physics, BSc in mathematics, and a MSc in theoretical physics. He conducted his PhD in experimental biophysics and cell-biology at the London Centre for Nanotechnology at the University College London, UK. He performed his Postdoctoral work at the University of Oxford in close collaboration with the Howard Hughes Medical Institute Janelia Farm, USA. In 2016, his independent research group was initially established at the Weatherall Institute for Molecular Medicine at the University of Oxford. The BPI lab moved to the Franklin and Kennedy in 2020. He became Scientific Director of the Oxford-ZEISS Centre of Excellence in 2021 and full Professor in 2023.

His current research includes the development and application of optical microscopy, sensitive force probing technologies, and analysis pipe-lines for quantitative bio-imaging.

Projects and Platforms
Publications

Actin waves guide an outward movement of microclusters in the lymphocyte immunological synapse

BioRxiv

2025, Journal Article

DOI: 10.1101/2025.06.20.660656

Long-range formation of the Bicoid gradient requires multiple dynamic modes that spatially vary across the embryo

DEVELOPMENT

2024, Journal Article

DOI: 10.1242/DEV.202128

Mechanical force matters in early T cell activation

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

2024, Journal Article

DOI: 10.1073/PNAS.2404748121

Semaphorin 3A causes immune suppression by inducing cytoskeletal paralysis in tumour-specific CD8<SUP>+</SUP> T cells (vol 15, 3448 , 2024)

NATURE COMMUNICATIONS

2024, Journal Article

DOI: 10.1038/S41467-024-47775-7

Semmaphorin 3 A causes immune suppression by inducing cytoskeletal paralysis in tumour-specific CD8<SUP>+</SUP> T cells

NATURE COMMUNICATIONS

2024, Journal Article

DOI: 10.1038/S41467-024-47424-Z

Intracellular trafficking of HLA-E and its regulation

JOURNAL OF EXPERIMENTAL MEDICINE

2023, Journal Article

DOI: 10.1084/JEM.20221941

Neutrophil nucleus: shaping the past and the future

JOURNAL OF LEUKOCYTE BIOLOGY

2023, Journal Article

DOI: 10.1093/JLEUKO/QIAD084

Single-cell phenomics reveals behavioural and mechanical heterogeneities underpinning collective migration during mouse anterior patterning

BioRxiv

2023, Journal Article

DOI: 10.1101/2023.03.31.534937

ASPP2 maintains the integrity of mechanically stressed pseudostratified epithelia during morphogenesis

Nature Communications

2022, Journal Article

FCHO controls AP2's initiating role in endocytosis through a Ptdlns(4,5)P<sub>2</sub>-dependent switch

SCIENCE ADVANCES

2022, Journal Article

DOI: 10.1126/SCIADV.ABN2018

Live microscopy: cracking the challenge to image biology unfolding in cells, tissues, and organs

COMMUNICATIONS BIOLOGY

2022, Journal Article

DOI: 10.1038/S42003-022-03601-8

Live microscopy: cracking the challenge to image biology unfolding in cells, tissues, and organs (vol 5, pg 665, 2022)

COMMUNICATIONS BIOLOGY

2022, Journal Article

DOI: 10.1038/S42003-022-03687-0

Mechanobiological control of T-cell activation

BIOPHYSICAL JOURNAL

2022, Journal Article