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Nanobody Discovery

Nanobodies are single domain antibodies derived from the unique heavy chain only immunoglobulins of camels, llamas, and alpacas.  Their small molecular size, high affinity and stability combine to make them unique targeting reagents with multiple applications in the biomedical sciences, including super-resolution microscopy and non-invasive imaging. In structural biology, the use of nanobodies has been transformative enabling the analysis of complex macromolecules including integral membrane proteins.

At the Franklin we have streamlined the generation and characterisation of nanobodies and are applying the technology to the diagnosis and treatment of emerging viral pathogens.

Through collaborative projects we aim to increase access to nanobodies for the UK research community.

For details of our nanobody protocols go to https://bio-protocol.org/e4962

Project team leader at the Franklin:

Project team members at the Franklin:


Rosalind Franklin Institute