Dr Siva Ramadurai
Siva is working as senior staff scientist in the structural biology theme, focusing on cell-free protein expression system for protein production, fluorescent microscopy, droplet-interface bilayer and cellular biophysics.
He completed B.Sc in Physics and M.Sc in Biophysics from University of Madras, India and Ph.D in Membrane Biophysics and Biochemistry from University of Groningen, The Netherlands. He worked as postdoctoral researcher in National University of Ireland Galway and Dublin City University, Ireland on projects to study interaction of biomolecules and drugs in the membrane and living cells. Before moving to the Franklin, Siva worked as postdoctoral research scientist at University of Oxford to establish cell-free protein expression system for protein production and droplet-interface bilayer.
Nanobodies Discovery Platform
Nanobodies are single domain antibodies derived from the unique heavy chain only immunoglobulins of camels, llamas, and alpacas.
Defining how coronaviruses enter and traffic in cells
Initial interactions between viruses and cells determine the course of infection. We are applying advanced imaging and biochemical methods to map the early events during infection by the model coronavirus OC43. Our work will reveal new strategies to target viral infections, including by potential future pandemic agents.