Volumetric imaging
Structural Neurobiology
Developing cutting edge techniques to image structures in the brain on the molecular scale so we can identify early structural changes leading to disease onset.
In Utero
Stillbirth is the result of varied processes taking place within both the mother’s and baby’s organs during pregnancy – a time of rapid changes.
Cryo-ptycho-tomography
Developing a novel technique using cryo-electron ptychography to perform tomographic characterisation of biological processes at cellular scales, enabling detailed study of rare and complex structures in their native environments.
Biochemical Microscopy for imaging across Molecular Scales
Developing a transformative cryogenic 3D biochemical microscope, harnessing the power of high-resolution electron microscopy and mass spectrometry imaging
Large Volume Tomography
High resolution large volume tomography with electron microscopy has the potential to transform our understanding of life, by linking the atomic and molecular structure of protein complexes in their biological context – the cell.
Cryogenic electron imaging for investigating the molecular sociology within cells and tissues
Electron imaging under cryogenic conditions allows cells and tissues to be imaged on multiple scales, with pristine preservation of fine molecular detail.
Emerging Interest Area: Structural Cell Pathology
The Franklin’s Emerging Interest Areas are developing areas of research led by our talented emerging leaders. These areas align with the Franklin’s mission of accelerating life science discovery and improving human health.
Quantitative Biology Across Scales
Our aim: To combine innovative imaging techniques and AI to extend imaging scales from cells to tissues and organs to transform clinical practice.