Microscopy
Defining how coronaviruses enter and traffic in cells
Initial interactions between viruses and cells determine the course of infection. We are applying advanced imaging and biochemical methods to map the early events during infection by the model coronavirus OC43. Our work will reveal new strategies to target viral infections, including by potential future pandemic agents.
Structural Glycobiology
Complex carbohydrate molecules are essential for life. These diverse structures are found on every human cell and participate in a huge range of structural and signalling functions within cells, and between cells and the extracellular matrix.
Electron Detector Development
Atomic resolution imaging with electrons causes sample damage. The information per unit of damage is dependent on sample thickness and beam energy.
Stimulated Emission Depletion Microscopy (STED)
We are from investigating how cells communicate with one another, to understand more complex structures such as those found in organoid and tissue formation.
Multidimensional Imaging
Our aim: To develop new technologies to see the molecules of life in more detail including their dynamics and chemistry.