Electron Ptychography and Phase Retrieval in Electron Microscopy
Cryogenic electron ptychography uses coherent diffractive imaging techniques with computational iterative phase retrieval algorithms.
New methods such as these are challenging but open the door to new tools for the scientific community. Simulations show that resolution achieved by cryo-ptychography could theoretically be decreased to 2.2 Å, but improved strategies are needed as this area of work applied to biology includes the careful balance between radiation damage and signal-to-noise. These methods could be used to examine biological structures at high-resolution using a small number of particles or over wide fields of view. We use our physics knowledge to work in the experimental, computational, and theoretical development of this field.
