Challenge Leadership Group

Dr Liang Wu

Deputy Challenge Lead and Glycobiology Scientist
About

Liang is a Wellcome Trust Sir Henry Dale fellow. He is establishing a lab to study the processes involved in formation of heparan sulfate, one of the essential polysaccharide (sugar) molecules produced by the body.

He studied Medicinal Chemistry at UCL, followed by a PhD at Cambridge studying the interactions between proteins and noncoding RNAs. He then moved to York for a postdoc, investigating the structures of sugar processing enzymes and their roles in biology, which is where his interest remains today.

Projects and Platforms
Publications

Structural glycobiology – from enzymes to organelles

Biochemical Society Transactions

27 Feb 2025, Journal Article

DOI: 10.1042/BST20241119

Molecular Basis for Inhibition of Heparanases and β-Glucuronidases by Siastatin B

Journal Of The American Chemical Society

10 Jan 2024, Journal Article

DOI: 10.1021/jacs.3c04162

Mechanism-based heparanase inhibitors reduce cancer metastasis in vivo

Proceedings Of The National Academy Of Sciences

2 Aug 2022, Journal Article

DOI: 10.1073/pnas.2203167119