Researchers

Professor Owen Rackham

Secondee
About
Owen is Professor of Artificial Intelligence for the Life Sciences at the University of Southampton and a current secondee to the Rosalind Franklin Institute. Trained originally as a computer scientist, his work focuses on understanding how biological systems function by bringing together data, algorithms and experimental insight.
Owen’s research addresses how genes and drugs coordinate changes in cellular phenotypes. Working closely with experimental scientists, he combines computational methods with real-world biology to better understand and treat disease.
At the Franklin, Owen is contributing to the development of a “virtual cell” . This work aims to create a digital representation of how cells work by bringing together diverse biological data to model and predict cellular behaviour. By building these tools, this project aims to create new ways for researchers to explore complex biological systems and accelerate discovery in health and life sciences.
Publications

Microprotein SMIM26 drives oxidative metabolism via serine-responsive mitochondrial translation

Molecular Cell

17 Jul 2025, Journal Article

DOI: 10.1016/j.molcel.2025.05.033

Personalized uncertainty quantification in artificial intelligence

Nature Machine Intelligence

23 Apr 2025, Journal Article

DOI: 10.1038/s42256-025-01024-8