James Conway

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PhD Student

Thesis Title: Probing Nuclear-Encoded Mitochondrial Protein Translocation Impairments in Cholinergic Neurodegeneration of Synucleinopathies.

Primary Theme: Correlated Imaging

Secondary Theme: Structural Biology

Franklin Supervisors: Dr Judy Kim, Dr Brian Caffrey, Dr Liang Wu.

University: University of Birmingham

University Supervisor: Dr Ilse Pienaar

External Supervisor: Prof. Daniel Tennant

James’ project is focused on interrogating the behaviour of nuclear-encoded mitochondrial proteins implicated in Lewy Body Dementia. The inappropriate signalling of important nuclear-encoded proteins involved in maintaining mitochondrial function and homeostasis may be the basis of mitochondrial aberrations in synucleinopathy disorders. Here, he will use Scanning Transmission Electron Microscopy (STEM) and super-resolution light microscopy techniques such as Stimulated Emission Depletion (STED) to elucidate the behaviour of key nuclear-encoded mitochondrial proteins which are implicated in such disorders.

James graduated from the University of Warwick with an integrated master’s in Biomedical Science. For his master’s project, he investigated the relationship between genetic polymorphisms within Human papillomavirus and cervical cancer.