Researchers

Dr Lucile Moynie

Senior Scientist in Structural Biology and Protein Science
Lucile Moynie
About

After completing her PhD in Structural Biology, Lucile moved to St Andrews as a research fellow where she studied protein structure-activity relationship (SAR), antimicrobial drug development, antibiotic uptake and resistance and membrane protein. Lucile then moved to the University of Oxford before joining the Franklin as an Associate Investigator in Structural Biology.

Publications

A FtsZ inhibitor-acinetobactin conjugate with enhanced cellular uptake in Acinetobacter baumannii acts synergistically in combination with PBP3-targeting antibiotics

PLOS One

14 Oct 2025, Journal Article

DOI: 10.1371/journal.pone.0334409

Structure of the Outer Membrane Transporter FemA and Its Role in the Uptake of Ferric Dihydro-Aeruginoic Acid and Ferric Aeruginoic Acid in <i>Pseudomonas aeruginosa</i>

ACS Chemical Biology

21 Mar 2025, Journal Article

DOI: 10.1021/acschembio.4c00820

Covalent penicillin-protein conjugates elicit anti-drug antibodies that are clonally and functionally restricted

Nature Communications

10 Aug 2024, Journal Article

DOI: 10.1038/s41467-024-51138-7

Studies of antibacterial activity (in vitro and in vivo) and mode of action for des-acyl tridecaptins (DATs)

European Journal Of Medicinal Chemistry

Feb 2024, Journal Article

DOI: 10.1016/j.ejmech.2023.116097

Correlation between the binding affinity and the conformational entropy of nanobody SARS-CoV-2 spike protein complexes.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Jul 2022, Journal Article

DOI: 10.1073/pnas.2205412119

Hijacking of the Enterobactin Pathway by a Synthetic Catechol Vector Designed for Oxazolidinone Antibiotic Delivery in <i>Pseudomonas aeruginosa</i>.

ACS Infectious Diseases

Jul 2022, Journal Article

DOI: 10.1021/acsinfecdis.2c00202

A potent SARS-CoV-2 neutralising nanobody shows therapeutic efficacy in the Syrian golden hamster model of COVID-19.

Nature Communications

Sep 2021, Journal Article

DOI: 10.1038/s41467-021-25480-z

A potent SARS-CoV-2 neutralising nanobody shows therapeutic efficacy in the Syrian golden hamster model of COVID-19

Jul 2021, Preprint

DOI: 10.21203/rs.3.rs-548968/v1

Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2.

Nature Structural & Molecular Biology

Jul 2020, Journal Article

DOI: 10.1038/s41594-020-0469-6

Porins and small-molecule translocation across the outer membrane of Gram-negative bacteria

Nature Reviews Microbiology

2 Dec 2019, Journal Article

DOI: 10.1038/s41579-019-0294-2

The complex of ferric-enterobactin with its transporter from Pseudomonas aeruginosa suggests a two-site model

Nature Communications

14 Aug 2019, Journal Article

DOI: 10.1038/s41467-019-11508-y

Complexes formed by the siderophore-based monosulfactam antibiotic BAL30072 and their interaction with the outer membrane receptor PiuA of P. aeruginosa

BioMetals

11 Feb 2019, Journal Article

DOI: 10.1007/s10534-018-00166-0

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