Structural biology
Structural Neurobiology
Developing cutting edge techniques to image structures in the brain on the molecular scale so we can identify early structural changes leading to disease onset.
Structural Glycobiology
Complex carbohydrate molecules are essential for life. These diverse structures are found on every human cell and participate in a huge range of structural and signalling functions within cells, and between cells and the extracellular matrix.
Electron Diffraction
MicroED is an emerging technology that exploits the strong interaction of electrons to reveal the structures of molecules from vanishingly small crystals.
Cryo-ptycho-tomography
Developing a novel technique using cryo-electron ptychography to perform tomographic characterisation of biological processes at cellular scales, enabling detailed study of rare and complex structures in their native environments.
Emerging Interest Area: Structural Cell Pathology
The Franklin’s Emerging Interest Areas are developing areas of research led by our talented emerging leaders. These areas align with the Franklin’s mission of accelerating life science discovery and improving human health.
Capturing Complexity: How AntigenApp Is Transforming Nanobody Discovery at the Franklin
Researchers at the Franklin studying schistosomiasis- a neglected tropical disease affecting more than 200 million people globally- have now observed the structure of a key protein thanks to a unique blend of nanobody discovery and advanced data science. Cracking the…