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Chromatic correction

The Franklin is developing a chromatically corrected column fitted with a new Cc corrector design in conjunction with Cs (spherical) aberration correction. This instrument will also be fitted with high speed electrostatic shutters, fast direct electron detectors and a robotic autoloader. This technology will enable structural studies of thicker biological samples.

Currently TEM imaging of thicker samples is resolution limited by the effects of chromatic defocus, an effect which becomes more severe at lower voltage. EM studies of thicker specimens would open the door to larger functional structures but could also mean high-resolution data in native liquid environments. This should enable imaging of smaller molecules in their active environment of interest without the precision sample fabrication methods currently necessary.

Project team members at The Franklin:

Project partners:


Rosalind Franklin Institute