Virus
Applying artificial intelligence to accelerate the discovery of anti-viral nanobodies
Nanobodies are single domain antibodies derived from the unique heavy chain only immunoglobulins of camelids. Their rapid generation is important for pandemic preparedness as they can be used in diagnostic tests. We will use machine learning tools to accelerate the discovery of nanobodies to norovirus, which causes stomach flu.
Defining how coronaviruses enter and traffic in cells
Initial interactions between viruses and cells determine the course of infection. We are applying advanced imaging and biochemical methods to map the early events during infection by the model coronavirus OC43. Our work will reveal new strategies to target viral infections, including by potential future pandemic agents.
How Pathogens Interact with Human Cells
Our aim: To discover new ways of detecting, preventing and combatting human infectious diseases by discovering the mechanisms by which viruses and bacteria interact with human cells and tissues.