Time Resolved Ptychography

This instrument will enable structural studies of smaller molecules in native environments. 

The Franklin is developing a new double aberration corrected column, which will open up new imaging modes not available in conventional cryo-EM instruments. The increased phase sensitivity of ptychography will enable structural studies of smaller molecules at lower doses and will require fewer particles for single-particle 3D reconstruction. This instrument will also include high speed electrostatic shutters which will enable a pulsed mode operation.